Adefovir Online



How and where to order Hepsera (Adefovir Dipivoxil) 10 mg tablets online on NNEPI:

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Adefovir (trade names include Hepsera, Adesera, Adfovir, Hepfovir, Preveon) is an antiviral medication from nucleoside and nucleotide reverse transcriptase inhibitors pharmacological group. This medicine is used for the treatment of chronic infection caused by hepatitis B virus. It is indicated in a prodrug form called Adefovir Dipivoxil. Hepsera works by blocking reverse transcriptase, an enzyme crucial for the HBV to reproduce in the body.


Adefovir Dipivoxil (Hepsera) 10 mg tablets


Related medications:

  • Abacavir (Ziagen)
  • Clevudine (Levovir, Revovir)
  • Didanosine (Videx)
  • Emtricitabine (Emtriva)
  • Entecavir (Baraclude)
  • Lamivudine (Epivir)
  • Stavudine (Zerit)
  • Telbivudine (Sebivo, Tyzeka)
  • Tenofovir Alafenamide (Vemlidy)
  • Tenofovir Disoproxil (Viread)
  • Zalcitabine (Hivid)
  • Zidovudine (Retrovir)


    Pharmacological and medical categories:

  • Anti hepatitis drugs
  • Anti-infective agents
  • Antiviral medications
  • Medicines for the therapy of chronic HBV infection
  • Nucleosides and nucleotides
  • Reverse-transcriptase inhibitor (ntRTI) analogs


    ATC codes:

  • J - Antiinfectives for systemic use
  • J05 - Antivirals for systemic use
  • J05A - Direct acting antivirals
  • J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
  • J05AF08 - Adefovir Dipivoxil


    ICD-10 codes:

  • Chronic viral hepatitis - B18
  • Chronic viral hepatitis B with delta-agent - B18.0
  • Chronic viral hepatitis B without delta-agent - B18.1


    Indications and usage:

    Hepsera (Adefovir Dipivoxil) is a nucleotide analogue indicated for the treatment ofchronic hepatitis B inpatients12yearsof ageandolder.


    Dosage and administration:

  • One tablet containing 10 mg adefovir dipivoxil once daily orally with or without food.
  • Dose adjustment in renal impairment for adults.
  • No dose recommendations for non-hemodialysis patients with creatinine clearance less than 10 mL per minute and adolescent patients with renal impairment.


    Dosage forms and strengths:

    Hepsera (Adefovir Dipivoxil) tablets 10 mg.


    Overdosage:

    Doses of adefovir dipivoxil 500 mg daily for 2 weeks and 250 mg daily for 12 weeks have been associated with gastrointestinal side effects. If overdose occurs the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.

    Following a 10 mg single dose of Hepsera, a four-hour hemodialysis session removed approximately 35% of the adefovir dose.


    Contraindications:

    Hepsera is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product.


    Warnings and precautions:

  • Severe acute exacerbations of hepatitis: monitor hepatic function closely at repeated intervals for at least several months in patients who discontinue Hepsera.
  • Nephrotoxicity: monitor renal function during therapy for all patients, particularly those with pre-existing or other risks for renal impairment. Dose adjustment may berequired.
  • HIV resistance: offer HIV testing to all patients prior to initiating Hepsera (Adefovir Dipivoxil). Untreated HIV may result in HIV resistance.
  • Lactic acidosis and severe hepatomegaly with steatosis: if suspected, suspend treatment.
  • Coadministration with other products: do not administer adefovir tablets concurrently with tenofovir-containing products.
  • Clinical resistance: for patients with lamivudine-resistant HBV use adefovir dipivoxil in combination with lamivudine. For all patients, consider modifying treatment in caseserum HBV DNA remains above 1000 copies/mL with continuedtreatment.


    Side effects, adverse reactions:

    Most common adverse reactions (incidence greater than 5%) in compensated liver disease patients were asthenia, headache, abdominal pain and nausea.

    The most common side effects in pre-and post-transplantation lamivudine-resistant liver disease patients was increased creatinine.

    To report suspected adverse reactions, contact Gilead or your local FDA.


    Drug interactions:

    Coadministration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of adefovir or the coadministereddrug. Monitor for Hepsera associated adverse events.


    Use in specific populations:

  • Pediatrics: not recommended in children less than 12 years of age.
  • Renal impairment: dose adjustment maybe required.


    Pregnancy categories:

  • B3 - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other forms:

  • Adefovir Base
  • Adefovir Dipivoxil


    Synonyms, international and chemical names:

  • Adefovir Dipivoksil
  • bis-POM PMEA
  • C8H12N5O4P


    Brands, generics, trade names:

  • Adefovir - Apotex, SigmaPharm Laboratories, Stada
  • Adesera - Cipla
  • Adfovir - Sun Pharmaceutical Industries
  • Hepfovir - Incepta Pharmaceuticals
  • Hepsera - Gilead, Bristol-Myers Squibb, Firma Chun Cheong, GlaxoSmithKline, Orphan Pharmaceutical, TRB Chemedica, UCB Pharma, Zuellig Pharma
  • Preveon - Gilead


    Here is a list of popular medications containing adefovir as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Adesera
  • Tablets; Oral; Adefovir Dipivoxil 10 mg
  • Cipla
  • Adfovir
  • Tablets; Oral; Adefovir Dipivoxil 10 mg
  • Sun Pharmaceutical Industries
  • Hepsera
  • Tablets; Oral; Adefovir Dipivoxil 10 mg
  • Gilead



  • References:

  • Adefovir main article on Wikipedia: https://en.wikipedia.org/wiki/Adefovir
  • Adefovir compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Adefovir
  • Adefovir Dipivoxil compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Adefovir-dipivoxil
  • Adefovir on DrugBank: https://go.drugbank.com/drugs/DB13868
  • Adefovir Dipivoxil on DrugBank: https://go.drugbank.com/drugs/DB00718
  • Adefovir FAQ on MedlinePlus (revised 05/15/2018): https://medlineplus.gov/druginfo/meds/a605024.html
  • Hepsera (Adefovir Dipivoxil) tablets 10 mg drug label information on DailyMed (revised December 1, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Adefovir Dipivoxil tablets 10 mg by Sigmapharm Laboratories LLC drug label information on DailyMed (revised August 6, 2018): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Adefovir containing drugs on Drugs-About.com: https://drugs-about.com/ing/adefovir.html
  • Adefovir for sale on Pharma Doctor: https://pharma-doctor.com/adefovir.html
  • Hepsera (Adefovir Dipivoxil) tablets 10 mg for oral use official prescribing and patient information from the U.S. FDA (revised November 2012): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Hepsera (Adefovir Dipivoxil) tablets 10 mg for oral use prescribing and patient information from Gilead Sciences (revised December 2018): https://www.gilead.com/-/media/files/pdfs/...
  • Hepsera (Adefovir Dipivoxil) products information from EMA: https://www.ema.europa.eu/en/medicines/human/EPAR/hepsera
  • Hepsera (Adefovir Dipivoxil) tablets 10 mg package information leaflet from Medicines.org.uk (revised 07/2019): https://www.medicines.org.uk/emc/files/pil.6810.pdf

    Revised: March 2021



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